Assay Detail
Binding
CHEMBL4373196
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HGFA catalytic domain (unknown origin) preincubated for 30 mins followed by Boc-QLR-AMC substrate addition and measured for 1 hr by fluorescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hepatocyte growth factor activator (CHEMBL3351190) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.73 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454016 | — | — | 1 | 7.52 |
| CHEMBL4540950 | — | — | 1 | 7.48 |
| CHEMBL4561858 | — | — | 1 | 6.33 |
| CHEMBL4528632 | — | — | 1 | 6.02 |
| CHEMBL4552828 | — | — | 1 | 5.92 |
| CHEMBL4460256 | — | — | 1 | 5.53 |
| CHEMBL4528379 | — | — | 1 | 5.50 |
| CHEMBL4445232 | — | — | 1 | 5.37 |
| CHEMBL4472547 | — | — | 1 | 5.33 |
| CHEMBL4463174 | — | — | 1 | 5.32 |
| CHEMBL4551624 | — | — | 1 | 5.21 |
| CHEMBL4567317 | — | — | 1 | 5.17 |
| CHEMBL4562668 | — | — | 1 | 5.10 |
| CHEMBL4562796 | — | — | 1 | 5.06 |
| CHEMBL4548036 | — | — | 1 | 5.03 |
| CHEMBL4467638 | — | — | 1 | - |
| CHEMBL4571215 | — | — | 1 | - |
| CHEMBL4469801 | — | — | 1 | - |
| CHEMBL4472544 | — | — | 1 | - |
| CHEMBL4462941 | — | — | 1 | - |
| CHEMBL4455095 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454016 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4540950 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4561858 | — | Ki | = | 468.0 | nM | 6.33 |
| CHEMBL4528632 | — | Ki | = | 963.0 | nM | 6.02 |
| CHEMBL4552828 | — | Ki | = | 1208.0 | nM | 5.92 |
| CHEMBL4460256 | — | Ki | = | 2961.0 | nM | 5.53 |
| CHEMBL4528379 | — | Ki | = | 3197.0 | nM | 5.50 |
| CHEMBL4445232 | — | Ki | = | 4303.0 | nM | 5.37 |
| CHEMBL4472547 | — | Ki | = | 4634.0 | nM | 5.33 |
| CHEMBL4463174 | — | Ki | = | 4771.0 | nM | 5.32 |
| CHEMBL4551624 | — | Ki | = | 6122.0 | nM | 5.21 |
| CHEMBL4567317 | — | Ki | = | 6827.0 | nM | 5.17 |
| CHEMBL4562668 | — | Ki | = | 7984.0 | nM | 5.10 |
| CHEMBL4562796 | — | Ki | = | 8634.0 | nM | 5.06 |
| CHEMBL4548036 | — | Ki | = | 9375.0 | nM | 5.03 |
| CHEMBL4467638 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4571215 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4469801 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4472544 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4462941 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4455095 | — | Ki | > | 10000.0 | nM | - |