Assay Detail
Binding
CHEMBL4373201
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins followed by substrate addition and measured over 1 hr by fluorescence assay
106
Total Activities
106
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit (CHEMBL3341578) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli (strain K12) |
Publication
α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 106 | 5.03 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4551942 | — | — | 1 | 6.30 |
| CHEMBL4448860 | — | — | 1 | 6.30 |
| CHEMBL4444802 | — | — | 1 | 6.22 |
| CHEMBL4483092 | — | — | 1 | 6.22 |
| CHEMBL4575669 | — | — | 1 | 5.09 |
| CHEMBL4472140 | — | — | 1 | 4.88 |
| CHEMBL4446383 | — | — | 1 | 4.85 |
| CHEMBL4461379 | — | — | 1 | 4.84 |
| CHEMBL4561263 | — | — | 1 | 4.42 |
| CHEMBL3770879 | — | — | 1 | 4.40 |
| CHEMBL4585066 | — | — | 1 | 4.32 |
| CHEMBL4469279 | — | — | 1 | 4.30 |
| CHEMBL4442349 | — | — | 1 | 4.15 |
| CHEMBL4476496 | — | — | 1 | 4.10 |
| CHEMBL4456475 | — | — | 1 | - |
| CHEMBL4449224 | — | — | 1 | - |
| CHEMBL4435181 | — | — | 1 | - |
| CHEMBL4513583 | — | — | 1 | - |
| CHEMBL4544287 | — | — | 1 | - |
| CHEMBL4544174 | — | — | 1 | - |
| CHEMBL4559730 | — | — | 1 | - |
| CHEMBL4440311 | — | — | 1 | - |
| CHEMBL4440015 | — | — | 1 | - |
| CHEMBL4458565 | — | — | 1 | - |
| CHEMBL4568558 | — | — | 1 | - |
| CHEMBL4444920 | — | — | 1 | - |
| CHEMBL4448396 | — | — | 1 | - |
| CHEMBL4464045 | — | — | 1 | - |
| CHEMBL4437668 | — | — | 1 | - |
| CHEMBL4438438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448860 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4551942 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4483092 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4444802 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4575669 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4472140 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL4446383 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL4461379 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4561263 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3770879 | — | IC50 | = | 39800.0 | nM | 4.40 |
| CHEMBL4585066 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL4469279 | — | IC50 | = | 49500.0 | nM | 4.30 |
| CHEMBL4442349 | — | IC50 | = | 71300.0 | nM | 4.15 |
| CHEMBL4476496 | — | IC50 | = | 79700.0 | nM | 4.10 |
| CHEMBL4544801 | — | IC50 | - | — | - | |
| CHEMBL4517157 | — | IC50 | - | — | - | |
| CHEMBL4452077 | — | IC50 | - | — | - | |
| CHEMBL4451640 | — | IC50 | - | — | - | |
| CHEMBL4476717 | — | IC50 | - | — | - | |
| CHEMBL4462723 | — | IC50 | - | — | - | |
| CHEMBL4438501 | — | IC50 | - | — | - | |
| CHEMBL4449129 | — | IC50 | - | — | - | |
| CHEMBL4593483 | — | IC50 | - | — | - | |
| CHEMBL4532659 | — | IC50 | - | — | - | |
| CHEMBL4513936 | — | IC50 | - | — | - | |
| CHEMBL4460911 | — | IC50 | - | — | - | |
| CHEMBL4587430 | — | IC50 | - | — | - | |
| CHEMBL4546615 | — | IC50 | - | — | - | |
| CHEMBL4466511 | — | IC50 | - | — | - | |
| CHEMBL4532734 | — | IC50 | - | — | - | |
| CHEMBL4545719 | — | IC50 | - | — | - | |
| CHEMBL4519525 | — | IC50 | - | — | - | |
| CHEMBL4563688 | — | IC50 | - | — | - | |
| CHEMBL393591 | — | IC50 | - | — | - | |
| CHEMBL4436632 | — | IC50 | - | — | - | |
| CHEMBL4442639 | — | IC50 | - | — | - | |
| CHEMBL4550461 | — | IC50 | - | — | - | |
| CHEMBL4524547 | — | IC50 | - | — | - | |
| CHEMBL4559386 | — | IC50 | - | — | - | |
| CHEMBL4540480 | — | IC50 | - | — | - | |
| CHEMBL4516940 | — | IC50 | - | — | - | |
| CHEMBL4527515 | — | IC50 | - | — | - | |
| CHEMBL4551194 | — | IC50 | - | — | - | |
| CHEMBL4560967 | — | IC50 | - | — | - | |
| CHEMBL4475830 | — | IC50 | - | — | - | |
| CHEMBL4522091 | — | IC50 | - | — | - | |
| CHEMBL4544896 | — | IC50 | - | — | - | |
| CHEMBL4585121 | — | IC50 | - | — | - | |
| CHEMBL4519292 | — | IC50 | - | — | - | |
| CHEMBL4475828 | — | IC50 | - | — | - |