Assay Detail
ADMET
CHEMBL4373380
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE2A using cAMP as substrate measured after 60 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel, potent, selective, and brain penetrant phosphodiesterase 10A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.56 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4580449 | — | — | 1 | 6.04 |
| CHEMBL4569753 | — | — | 1 | 5.88 |
| CHEMBL4556703 | — | — | 1 | 5.88 |
| CHEMBL4535938 | — | — | 1 | 5.73 |
| CHEMBL1086110 | — | — | 1 | 5.67 |
| CHEMBL4542237 | — | — | 1 | 5.52 |
| CHEMBL4456157 | — | — | 1 | 5.45 |
| CHEMBL4464637 | — | — | 1 | 5.31 |
| CHEMBL4472846 | — | — | 1 | 5.27 |
| CHEMBL4437406 | — | — | 1 | 4.89 |
| CHEMBL4534373 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4580449 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL4569753 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL4556703 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4535938 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL1086110 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4542237 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4456157 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL4464637 | — | IC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL4472846 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4437406 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL4534373 | — | IC50 | > | 100000.0 | nM | - |