Assay Detail
Binding
CHEMBL4373750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TBK1 (unknown origin) using biotinylated peptide as substrate preincubated for 30 mins by fluorescence activity-based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TBK1 (CHEMBL5408) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.22 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3604928 | — | — | 1 | 10.22 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3604928 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 6.22 | nM | 8.21 |