Assay Detail

CHEMBL4374104

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Binding

Inhibition of Mycobacterium tuberculosis H37Rv leuRS

ChEMBL ↗

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Target

Leucine--tRNA ligase (CHEMBL4105844) ↗

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Leucine--tRNA ligase (CHEMBL4105844) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Leucine--tRNA ligase

CHEMBL4105844

Anchored from Assay target.

Protein identity Leucine--tRNA ligase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mycobacterium tuberculosis H37Rv
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Leucine--tRNA ligase (CHEMBL4105844) ↗

Type	SINGLE PROTEIN
Organism	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Publication

Recent development of leucyl-tRNA synthetase inhibitors as antimicrobial agents.

Zhang P, Ma S.
Medchemcomm (2019) 10 : 1329 -1341
PubMed 31534653 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.43	6.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4518074	—	—	1	6.19
CHEMBL378506	BENZOXABOROLE	—	1	4.67

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4518074	—	IC50	=	640.0	nM	6.19
CHEMBL378506	BENZOXABOROLE	IC50	=	21300.0	nM	4.67