Leucine--tRNA ligase · SINGLE PROTEIN · Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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As of 2026-09-14Protein identity stays anchored to UniProt P9WFV1. Use UniProt P9WFV1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P9WFV1 as the stable identity anchor, then attach disease evidence before program review.
Leucine--tRNA ligase
Review this target as Leucine--tRNA ligase, mapped to UniProt P9WFV1. Sequence length is 969 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Leucine--tRNA ligase as ChEMBL target CHEMBL4105844, mapped to UniProt P9WFV1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Leucine--tRNA ligase |
| Target Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| UniProt | P9WFV1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Leucine--tRNA ligase |
| UniProt Accession | P9WFV1 |
| Component Type | Protein |
| Sequence Length | 969 aa |
Leucine--tRNA ligase
Review this target as Leucine--tRNA ligase, mapped to UniProt P9WFV1. Sequence length is 969 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4105269 | 7.34 | IC50 | 46.0 | Preclinical |
| CHEMBL4077894 | 7.25 | IC50 | 56.0 | Preclinical |
| CHEMBL4086672 | 7.13 | IC50 | 74.0 | Preclinical |
| CHEMBL4075879 | 7.12 | IC50 | 75.0 | Preclinical |
| CHEMBL4104309 | 7.12 | IC50 | 76.0 | Preclinical |
| CHEMBL4102148 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL4082544 | 7.04 | IC50 | 92.0 | Preclinical |
| CHEMBL4066833 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL4081207 | 6.92 | IC50 | 120.0 | Preclinical |
| CHEMBL4081755 | 6.89 | IC50 | 130.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 8 | 4.9 |
| assay format | 1 | 44 | 6.5 |
| single protein format | 1 | 2 | 5.4 |