Compound Detail
CHEMBL4102148
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Basic Information
| ChEMBL ID | CHEMBL4102148 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DMAVCLMJKGWOIF-MRVPVSSYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
225.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Leucine--tRNA ligase CHEMBL4105844 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leucine--tRNA ligase | IC50 | = | 80.0 | nM | 7.1 | Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expr... | 28953378 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28953378 | 10.1021/acs.jmedchem.7b00631 | Leucine--tRNA ligase | 1 |
| 28953378 | 10.1021/acs.jmedchem.7b00631 | Mycobacterium tuberculosis | 1 |
Data from ChEMBL 36 via Core Engine