Assay Detail
ADMET
CHEMBL4374121
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Inhibition of human mitochondrial ribosome Mit 13 hybridized with Mycobacterium smegmatis ribosome assessed as inhibition of translation activity using Firefly luciferase mRNA reporter based luminescence analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4'-derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.38 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1572 | NETILMICIN | 4.0 | 1 | 4.55 |
| CHEMBL4444392 | — | — | 1 | 4.54 |
| CHEMBL4543487 | — | — | 1 | 4.31 |
| CHEMBL4439463 | — | — | 1 | 4.28 |
| CHEMBL4531998 | — | — | 1 | 4.24 |
| CHEMBL4538701 | — | — | 1 | - |
| CHEMBL4453596 | — | — | 1 | - |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | - |
| CHEMBL4439765 | — | — | 1 | - |
| CHEMBL4470951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1572 | NETILMICIN | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4444392 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4543487 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL4439463 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL4531998 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL4538701 | — | IC50 | = | 167000.0 | nM | - |
| CHEMBL4453596 | — | IC50 | = | 166000.0 | nM | - |
| CHEMBL370143 | PAROMOMYCIN | IC50 | = | 142000.0 | nM | - |
| CHEMBL4439765 | — | IC50 | = | 256000.0 | nM | - |
| CHEMBL4470951 | — | IC50 | = | 408000.0 | nM | - |