Assay Detail
Binding
CHEMBL4374468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at GST-tagged FXR-LBD (unknown origin) assessed as biotinylated SRC-1 recruitment after 30 mins by Alpha Screen assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dissecting the allosteric FXR modulation: a chemical biology approach using guggulsterone as a chemical tool.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.10 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240597 | CHENODIOL | 4.0 | 1 | 5.10 |
| CHEMBL402063 | E-GUGGULSTERONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240597 | CHENODIOL | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL402063 | E-GUGGULSTERONE | EC50 | > | 100000.0 | nM | - |