Assay Detail
Binding
CHEMBL4375022
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Inhibition of Staphylococcus aureus DNA gyrase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.34 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448131 | — | — | 1 | 8.10 |
| CHEMBL1235773 | — | — | 1 | 7.85 |
| CHEMBL3317856 | GEPOTIDACIN | 3.0 | 1 | 7.33 |
| CHEMBL4531538 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448131 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1235773 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3317856 | GEPOTIDACIN | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4531538 | — | IC50 | = | 830.0 | nM | 6.08 |