Assay Detail
Binding
CHEMBL4375032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 20S proteasome beta 1c derived from human erythrocytes preincubated for 1 hr using Z-nLPnLD-Glo peptide as substrate by proteasome-glo caspase-like assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.95 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.50 |
| CHEMBL4468132 | — | — | 1 | 7.21 |
| CHEMBL4445016 | — | — | 1 | 7.15 |
| CHEMBL4437785 | — | — | 1 | 6.32 |
| CHEMBL4516876 | — | — | 1 | 6.28 |
| CHEMBL4580854 | — | — | 1 | 5.85 |
| CHEMBL4460338 | — | — | 1 | 5.85 |
| CHEMBL4558093 | — | — | 1 | 5.38 |
| CHEMBL4542860 | — | — | 1 | 5.26 |
| CHEMBL4576544 | — | — | 1 | 4.96 |
| CHEMBL3237875 | — | — | 1 | 4.89 |
| CHEMBL4435165 | — | — | 1 | 4.75 |
| CHEMBL4573625 | — | — | 1 | - |
| CHEMBL4470266 | — | — | 1 | - |
| CHEMBL4465040 | — | — | 1 | - |
| CHEMBL4519222 | — | — | 1 | - |
| CHEMBL4471761 | — | — | 1 | - |
| CHEMBL4565027 | — | — | 1 | - |
| CHEMBL4452844 | — | — | 1 | - |
| CHEMBL4543890 | — | — | 1 | - |
| CHEMBL4542913 | — | — | 1 | - |
| CHEMBL4458214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4468132 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4445016 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4437785 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4516876 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4580854 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4460338 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4558093 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4542860 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4576544 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3237875 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4435165 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4573625 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4470266 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4465040 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4519222 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4471761 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4565027 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4452844 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4543890 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4542913 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4458214 | — | IC50 | > | 20000.0 | nM | - |