Compound Detail
CHEMBL4445016
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Basic Information
| ChEMBL ID | CHEMBL4445016 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TWDIPTOATPADJK-AWEZNQCLSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
316.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 9.26 | 7.642 | 0.6 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 0.55 | nM | 9.26 | Inhibition of human 20S proteasome beta 1i | 31283222 |
| Unchecked | IC50 | = | 4.0 | nM | 8.4 | Inhibition of human 20S proteasome beta 5i preincubated for 1 hr followed by flu... | 31283222 |
| Unchecked | IC50 | = | 45.0 | nM | 7.35 | Inhibition of 20S proteasome beta 5i/20S proteasome beta 1i in human PBMC cell l... | 31283222 |
| Unchecked | IC50 | = | 71.0 | nM | 7.15 | Inhibition of 20S proteasome beta 1c derived from human erythrocytes preincubate... | 31283222 |
| Unchecked | IC50 | = | 890.0 | nM | 6.05 | Inhibition of 20S proteasome beta 5c (unknown origin) preincubated for 1 hr foll... | 31283222 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31283222 | 10.1021/acs.jmedchem.9b00509 | Unchecked | 8 |
Data from ChEMBL 36 via Core Engine