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Assay Detail

CHEMBL4375086

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Binding
Inhibition of Bcl-XL (unknown origin) by fluorescence polarization assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bcl-2-like protein 1 (CHEMBL4625)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
Szlávik Z, Ondi L, Csékei M, Paczal A, Szabó ZB, Radics G, Murray J, Davidson J, Chen I, Davis B, Hubbard RE, Pedder C, Dokurno P, Surgenor A, Smith J, Robertson A, LeToumelin-Braizat G, Cauquil N, Zarka M, Demarles D, Perron-Sierra F, Claperon A, Colland F, Geneste O, Kotschy A.
J Med Chem (2019) 62 : 6913 -6924
PubMed 31339316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 4.56 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4460382 1 4.82
CHEMBL4455822 1 4.77
CHEMBL4472592 1 4.75
CHEMBL4450255 1 4.75
CHEMBL4514111 1 4.62
CHEMBL4442085 1 4.58
CHEMBL4573285 1 4.48
CHEMBL4521569 1 4.41
CHEMBL4443675 1 4.38
CHEMBL4456249 1 4.06
CHEMBL4440978 1 -
CHEMBL4455139 1 -
CHEMBL4471326 1 -
CHEMBL4448439 1 -
CHEMBL4436725 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4460382 Ki = 15000.0 nM 4.82
CHEMBL4455822 Ki = 17000.0 nM 4.77
CHEMBL4472592 Ki = 18000.0 nM 4.75
CHEMBL4450255 Ki = 18000.0 nM 4.75
CHEMBL4514111 Ki = 24000.0 nM 4.62
CHEMBL4442085 Ki = 26000.0 nM 4.58
CHEMBL4573285 Ki = 33000.0 nM 4.48
CHEMBL4521569 Ki = 39000.0 nM 4.41
CHEMBL4443675 Ki = 42000.0 nM 4.38
CHEMBL4456249 Ki = 87000.0 nM 4.06
CHEMBL4440978 Ki = 216000.0 nM -
CHEMBL4455139 Ki = 319000.0 nM -
CHEMBL4471326 Ki = 107000.0 nM -
CHEMBL4448439 Ki = 287000.0 nM -
CHEMBL4436725 Ki = 135000.0 nM -