Assay Detail
Functional
CHEMBL4375097
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Cytotoxicity against human NCI-H929 cells assessed as reduction in cell viability after 48 hrs in presence of ABT-263 by MTT assay
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.24 | 5.96 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4472351 | — | — | 2 | 5.96 |
| CHEMBL4451346 | — | — | 1 | 5.60 |
| CHEMBL4537357 | — | — | 1 | 5.38 |
| CHEMBL4450734 | — | — | 1 | 5.27 |
| CHEMBL4465591 | — | — | 1 | 5.16 |
| CHEMBL4573959 | — | — | 1 | 5.00 |
| CHEMBL4452383 | — | — | 1 | 4.91 |
| CHEMBL4437381 | — | — | 1 | - |
| CHEMBL4515048 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4472351 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4451346 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4537357 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4450734 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4465591 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4573959 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4452383 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4472351 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4437381 | — | Activity | - | — | - | |
| CHEMBL4515048 | — | Activity | - | — | - |