Assay Detail
ADMET
CHEMBL4375193
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Inhibition of N-terminal GST-tagged human EGFR (696 to end aminoacids) expressed in baculovirus infected Sf21 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.09 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436563 | — | — | 1 | 9.00 |
| CHEMBL4554990 | — | — | 1 | 8.40 |
| CHEMBL4528630 | — | — | 1 | 7.11 |
| CHEMBL4461455 | — | — | 1 | 6.85 |
| CHEMBL47940 | — | — | 1 | 6.75 |
| CHEMBL4468148 | — | — | 1 | 6.26 |
| CHEMBL4072833 | EVOBRUTINIB | 3.0 | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436563 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4554990 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4528630 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4461455 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL47940 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL4468148 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4072833 | EVOBRUTINIB | IC50 | = | 5800.0 | nM | 5.24 |