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Assay Detail

CHEMBL4375932

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against BHK21 cells assessed as reduction in cell viability after 48 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mesocricetus auratus
Cell Type BHK-21
Confidence 1 — Organism
Curated By Autocuration

Target

BHK-21 (CHEMBL614527)
Type CELL-LINE
Organism Mesocricetus auratus

Publication

Coumarin-containing hybrids and their anticancer activities.
Zhang L, Xu Z.
Eur J Med Chem (2019) 181 : 111587 -111587
PubMed 31404864 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.98 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4439249 1 6.00
CHEMBL4441645 1 6.00
CHEMBL4539544 1 6.00
CHEMBL4434896 1 6.00
CHEMBL4563218 1 6.00
CHEMBL4519233 1 6.00
CHEMBL4459992 1 6.00
CHEMBL4473974 1 6.00
CHEMBL4452542 1 6.00
CHEMBL90555 VINCRISTINE 4.0 1 5.97
CHEMBL4464038 1 5.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4439249 IC50 = 1010.0 nM 6.00
CHEMBL4441645 IC50 = 1010.0 nM 6.00
CHEMBL4539544 IC50 = 1010.0 nM 6.00
CHEMBL4434896 IC50 = 1010.0 nM 6.00
CHEMBL4563218 IC50 = 1010.0 nM 6.00
CHEMBL4519233 IC50 = 1010.0 nM 6.00
CHEMBL4459992 IC50 = 1010.0 nM 6.00
CHEMBL4473974 IC50 = 1010.0 nM 6.00
CHEMBL4452542 IC50 = 1010.0 nM 6.00
CHEMBL90555 VINCRISTINE IC50 = 1080.0 nM 5.97
CHEMBL4464038 IC50 = 1390.0 nM 5.86