Assay Detail
Binding
CHEMBL4376358
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Inhibition of PI3K p110beta (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.87 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545366 | VOXTALISIB | 2.0 | 1 | 6.95 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545366 | VOXTALISIB | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 166.0 | nM | 6.78 |