Assay Detail
Binding
CHEMBL4376479
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Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 5 mins by Ellman's method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.97 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.25 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.88 |
| CHEMBL4474399 | — | — | 1 | 6.44 |
| CHEMBL4455690 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 5.59 | nM | 8.25 |
| CHEMBL95 | TACRINE | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL4474399 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4455690 | — | IC50 | = | 480.0 | nM | 6.32 |