Assay Detail
Functional
CHEMBL4376733
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Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.25 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.46 |
| CHEMBL4520400 | — | — | 1 | 5.68 |
| CHEMBL4437895 | — | — | 1 | 5.53 |
| CHEMBL4560533 | — | — | 1 | 5.29 |
| CHEMBL4576056 | — | — | 1 | 5.26 |
| CHEMBL4452620 | — | — | 1 | 5.22 |
| CHEMBL4563224 | — | — | 1 | 5.09 |
| CHEMBL4472310 | — | — | 1 | 5.02 |
| CHEMBL4559559 | — | — | 1 | 4.99 |
| CHEMBL4565296 | — | — | 1 | 4.97 |
| CHEMBL4565392 | — | — | 1 | 4.85 |
| CHEMBL4464527 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL4520400 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4437895 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL4560533 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL4576056 | — | IC50 | = | 5460.0 | nM | 5.26 |
| CHEMBL4452620 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4563224 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL4472310 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL4559559 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4565296 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4565392 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4464527 | — | IC50 | = | 24800.0 | nM | 4.61 |