Assay Detail
Binding
CHEMBL4377063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TRPC5 expressed in HEK293 cells assessed as reduction in englerin A-induced calcium entry incubated for 30 mins by Fluo-4AM dye based fluorescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 5 (CHEMBL1250411) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Review of Transient Receptor Potential Canonical (TRPC5) Channel Modulators and Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.89 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4466522 | ZERENCOTREP | 2.0 | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4466522 | ZERENCOTREP | IC50 | = | 1.3 | nM | 8.89 |