Assay Detail
Binding
CHEMBL4377127
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HGPRT using Prib-PP as substrate by Hanes-plot based method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hypoxanthine-guanine phosphoribosyltransferase (CHEMBL2360) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.18 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4282830 | — | — | 1 | 8.89 |
| CHEMBL4290716 | — | — | 1 | 8.52 |
| CHEMBL4546337 | — | — | 1 | 7.00 |
| CHEMBL4561412 | — | — | 1 | 6.40 |
| CHEMBL4453040 | — | — | 1 | 5.10 |
| CHEMBL4439813 | — | — | 1 | - |
| CHEMBL2420976 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4282830 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4290716 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL4546337 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4561412 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL4453040 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL4439813 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL2420976 | — | Ki | = | 73000000.0 | nM | - |