Assay Detail
Binding
CHEMBL4377151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HGPRT assessed as inhibitor constant for enzyme-inhibitor complex formation using [5'-14C]IMP as substrate by scintillation counting method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hypoxanthine-guanine phosphoribosyltransferase (CHEMBL2360) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.93 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1233603 | — | — | 1 | 7.25 |
| CHEMBL1233663 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1233603 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL1233663 | — | Ki | = | 250.0 | nM | 6.60 |