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Assay Detail

CHEMBL4377284

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Binding
Inhibition of L3MBTL3 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Lethal(3)malignant brain tumor-like protein 3 (CHEMBL1287623)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
Xiong Y, Greschik H, Johansson C, Seifert L, Bacher J, Park KS, Babault N, Martini M, Fagan V, Li F, Chau I, Christott T, Dilworth D, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Brennan P, Fedorov O, Jung M, Farnie G, Liu J, Oppermann U, Schüle R, Jin J.
J Med Chem (2019) 62 : 8996 -9007
PubMed 31260300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.92 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2426364 1 6.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2426364 Kd = 120.0 nM 6.92