Assay Detail

CHEMBL4377462

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ADMET

Inhibition of JAK3 (unknown origin)

ChEMBL ↗

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Target

Tyrosine-protein kinase JAK3 (CHEMBL2148) ↗

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Tyrosine-protein kinase JAK3 (CHEMBL2148) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase JAK3

CHEMBL2148

Anchored from Assay target.

Protein identity Tyrosine-protein kinase JAK3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase JAK3 (CHEMBL2148) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.

Wrobleski ST, Moslin R, Lin S, Zhang Y, Spergel S, Kempson J, Tokarski JS, Strnad J, Zupa-Fernandez A, Cheng L, Shuster D, Gillooly K, Yang X, Heimrich E, McIntyre KW, Chaudhry C, Khan J, Ruzanov M, Tredup J, Mulligan D, Xie D, Sun H, Huang C, D'Arienzo C, Aranibar N, Chiney M, Chimalakonda A, Pitts WJ, Lombardo L, Carter PH, Burke JR, Weinstein DS.
J Med Chem (2019) 62 : 8973 -8995
PubMed 31318208 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.48	7.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4085457	RITLECITINIB	4.0	1	7.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4085457	RITLECITINIB	IC50	=	33.0	nM	7.48