Assay Detail
Functional
CHEMBL4377516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell viability after 72 hrs by CCK-8 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel cyclin-dependent kinase 9 (CDK9) inhibitor with suppression of cancer stemness activity against non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.14 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548580 | — | — | 1 | 5.25 |
| CHEMBL3545110 | RIBOCICLIB | 4.0 | 1 | 5.03 |
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548580 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL3545110 | RIBOCICLIB | IC50 | = | 9264.0 | nM | 5.03 |
| CHEMBL48802 | SULFORAPHANE | IC50 | > | 10000.0 | nM | - |