Assay Detail

CHEMBL4378250

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Functional

Cytotoxicity against human SH-SY5Y cells

ChEMBL ↗

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Target

SH-SY5Y (CHEMBL614910) ↗

Open DB target context

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SH-SY5Y (CHEMBL614910) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SH-SY5Y

CHEMBL614910

Anchored from Assay target.

Protein identity SH-SY5Y

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SH-SY5Y
Confidence	1 — Organism
Curated By	Autocuration

Target

SH-SY5Y (CHEMBL614910) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Drug Discovery Targeting Anaplastic Lymphoma Kinase (ALK).

Kong X, Pan P, Sun H, Xia H, Wang X, Li Y, Hou T.
J Med Chem (2019) 62 : 10927 -10954
PubMed 31419130 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.77	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4203266	—	—	1	8.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4203266	—	IC50	=	1.7	nM	8.77