Assay Detail
ADMET
CHEMBL4378667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human utrophin-1 in mouse mdx myoblasts by H2K-mdx utrnA-luc assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-<i>trans</i>-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.77 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1773683 | EZUTROMID | 2.0 | 1 | 6.96 |
| CHEMBL4442951 | — | — | 1 | 6.92 |
| CHEMBL4550375 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1773683 | EZUTROMID | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4442951 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4550375 | — | EC50 | = | 370.0 | nM | 6.43 |