Assay Detail
ADMET
CHEMBL4378668
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Activation of human utrophin-1 in iDMD cells by HTRF assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-<i>trans</i>-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.49 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1773683 | EZUTROMID | 2.0 | 1 | 5.89 |
| CHEMBL4442951 | — | — | 1 | 5.08 |
| CHEMBL4550375 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1773683 | EZUTROMID | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4442951 | — | EC50 | = | 8350.0 | nM | 5.08 |
| CHEMBL4550375 | — | EC50 | > | 10000.0 | nM | - |