Assay Detail
Functional
CHEMBL4378737
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Anti-neprotic activity in mouse MEF cells assessed as reduction in TNF-induced necroptosis and measured every 1 hr in presence of z-VAD by SYTOX Green dye based fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | MEF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.27 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441342 | — | — | 1 | 8.40 |
| CHEMBL2171124 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441342 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2171124 | — | IC50 | = | 7.3 | nM | 8.14 |