Assay Detail
Binding
CHEMBL4379510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 45Ca2+ uptake incubated for 5 mins by liquid scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.81 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448147 | — | — | 1 | 8.30 |
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 7.59 |
| CHEMBL313971 | ZUCAPSAICIN | 3.0 | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448147 | — | EC50 | = | 5.05 | nM | 8.30 |
| CHEMBL294199 | CAPSAICIN | EC50 | = | 25.9 | nM | 7.59 |
| CHEMBL313971 | ZUCAPSAICIN | EC50 | = | 28.2 | nM | 7.55 |