Compound Detail
CHEMBL313971
ZUCAPSAICIN 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL313971 |
| Name | ZUCAPSAICIN |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | YKPUWZUDDOIDPM-VURMDHGXSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
12
Publications
5
Known Names
6
Indications
1
Mechanisms
Molecular Properties
305.4
MW (Da)
3.79
ALogP
3
HBA
2
HBD
58.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Vanilloid receptor agonist | AGONIST | Transient receptor potential cation channel subfamily V member 1 | ✓ | ✓ |
Indications
Arthralgia Myalgia Osteoarthritis, Knee Pain Dry Eye Syndromes Neuralgia, Postherpetic
ATC Classification
M02AB02
zucapsaicin
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Activity Summary
EC50 1 meas. best 7.55
Ki 1 meas. best 5.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | EC50 | 7.55 | 7.55 | 28.2 | 1 |
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | Ki | 5.97 | 5.97 | 1080.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | EC50 | = | 28.2 | nM | 7.55 | Agonist activity at human TRPV1 expressed in CHO cells assessed as increase in 4... | 31702924 |
| Transient receptor potential cation channel subfamily V member 1 | Ki | = | 1080.0 | nM | 5.97 | Displacement of [3H]-RTX from human TRPV1 expressed in CHO cells incubated for 6... | 31702924 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8410971 | 10.1021/jm00070a002 | Mus musculus | 4 |
| 31702924 | 10.1021/acs.jmedchem.9b01046 | Transient receptor potential cation channel subfamily V member 1 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 8410971 | 10.1021/jm00070a002 | Rattus norvegicus | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| - | 10.6019/CHEMBL4513141 | Candida albicans | 1 |
| - | 10.6019/CHEMBL4513141 | Cryptococcus neoformans | 1 |
| - | 10.6019/CHEMBL4513141 | Escherichia coli | 1 |
| - | 10.6019/CHEMBL4513141 | Klebsiella pneumoniae | 1 |
| - | 10.6019/CHEMBL4513141 | Pseudomonas aeruginosa | 1 |
| - | 10.6019/CHEMBL4513141 | Acinetobacter baumannii | 1 |
| - | 10.6019/CHEMBL4513141 | Staphylococcus aureus | 1 |
Data from ChEMBL 36 via Core Engine