Assay Detail
ADMET
CHEMBL4379869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human carbonic anhydrase 4 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 5.98 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.13 |
| CHEMBL4442867 | — | — | 1 | 7.12 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 6.54 |
| CHEMBL4440314 | — | — | 1 | 6.42 |
| CHEMBL4444406 | — | — | 1 | 6.34 |
| CHEMBL4453203 | — | — | 1 | 6.34 |
| CHEMBL3976024 | — | — | 1 | 6.17 |
| CHEMBL4571323 | — | — | 1 | 6.15 |
| CHEMBL4542190 | — | — | 1 | 6.07 |
| CHEMBL4553482 | — | — | 1 | 6.05 |
| CHEMBL4550437 | — | — | 1 | 5.99 |
| CHEMBL4437873 | — | — | 1 | 5.91 |
| CHEMBL4435951 | — | — | 1 | 5.85 |
| CHEMBL4539322 | — | — | 1 | 5.81 |
| CHEMBL4587101 | — | — | 1 | 5.79 |
| CHEMBL4586255 | — | — | 1 | 5.76 |
| CHEMBL4531304 | — | — | 1 | 5.71 |
| CHEMBL4474233 | — | — | 1 | 5.57 |
| CHEMBL4536306 | — | — | 1 | 5.57 |
| CHEMBL4521083 | — | — | 1 | 5.46 |
| CHEMBL4449637 | — | — | 1 | 5.41 |
| CHEMBL4469385 | — | — | 1 | 5.23 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL4442867 | — | Ki | = | 76.1 | nM | 7.12 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 286.0 | nM | 6.54 |
| CHEMBL4440314 | — | Ki | = | 379.8 | nM | 6.42 |
| CHEMBL4444406 | — | Ki | = | 452.4 | nM | 6.34 |
| CHEMBL4453203 | — | Ki | = | 461.0 | nM | 6.34 |
| CHEMBL3976024 | — | Ki | = | 675.3 | nM | 6.17 |
| CHEMBL4571323 | — | Ki | = | 708.6 | nM | 6.15 |
| CHEMBL4542190 | — | Ki | = | 853.6 | nM | 6.07 |
| CHEMBL4553482 | — | Ki | = | 896.6 | nM | 6.05 |
| CHEMBL4550437 | — | Ki | = | 1031.0 | nM | 5.99 |
| CHEMBL4437873 | — | Ki | = | 1228.0 | nM | 5.91 |
| CHEMBL4435951 | — | Ki | = | 1427.0 | nM | 5.85 |
| CHEMBL4539322 | — | Ki | = | 1557.0 | nM | 5.81 |
| CHEMBL4587101 | — | Ki | = | 1637.0 | nM | 5.79 |
| CHEMBL4586255 | — | Ki | = | 1748.0 | nM | 5.76 |
| CHEMBL4531304 | — | Ki | = | 1945.0 | nM | 5.71 |
| CHEMBL4474233 | — | Ki | = | 2674.0 | nM | 5.57 |
| CHEMBL4536306 | — | Ki | = | 2692.0 | nM | 5.57 |
| CHEMBL4521083 | — | Ki | = | 3459.0 | nM | 5.46 |
| CHEMBL4449637 | — | Ki | = | 3894.0 | nM | 5.41 |
| CHEMBL4469385 | — | Ki | = | 5885.0 | nM | 5.23 |
| CHEMBL310671 | SACCHARIN | Ki | = | 7920.0 | nM | 5.10 |