Assay Detail
ADMET
CHEMBL4379870
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human carbonic anhydrase 7 incubated for 1 hr prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
"A Sweet Combination": Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.09 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 8.00 |
| CHEMBL4453203 | — | — | 1 | 6.90 |
| CHEMBL4550437 | — | — | 1 | 6.41 |
| CHEMBL4571323 | — | — | 1 | 6.36 |
| CHEMBL4539322 | — | — | 1 | 6.33 |
| CHEMBL3976024 | — | — | 1 | 6.33 |
| CHEMBL4542190 | — | — | 1 | 6.21 |
| CHEMBL4587101 | — | — | 1 | 6.16 |
| CHEMBL4553482 | — | — | 1 | 6.02 |
| CHEMBL4437873 | — | — | 1 | 6.01 |
| CHEMBL4586255 | — | — | 1 | 5.93 |
| CHEMBL4449637 | — | — | 1 | 5.89 |
| CHEMBL4531304 | — | — | 1 | 5.87 |
| CHEMBL4536306 | — | — | 1 | 5.75 |
| CHEMBL4435951 | — | — | 1 | 5.72 |
| CHEMBL4444406 | — | — | 1 | 5.59 |
| CHEMBL4440314 | — | — | 1 | 5.55 |
| CHEMBL4469385 | — | — | 1 | 5.49 |
| CHEMBL4474233 | — | — | 1 | 5.40 |
| CHEMBL4442867 | — | — | 1 | 5.30 |
| CHEMBL4521083 | — | — | 1 | 5.12 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL310671 | SACCHARIN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4453203 | — | Ki | = | 125.5 | nM | 6.90 |
| CHEMBL4550437 | — | Ki | = | 389.3 | nM | 6.41 |
| CHEMBL4571323 | — | Ki | = | 435.5 | nM | 6.36 |
| CHEMBL4539322 | — | Ki | = | 467.8 | nM | 6.33 |
| CHEMBL3976024 | — | Ki | = | 465.8 | nM | 6.33 |
| CHEMBL4542190 | — | Ki | = | 620.3 | nM | 6.21 |
| CHEMBL4587101 | — | Ki | = | 690.9 | nM | 6.16 |
| CHEMBL4553482 | — | Ki | = | 956.0 | nM | 6.02 |
| CHEMBL4437873 | — | Ki | = | 975.3 | nM | 6.01 |
| CHEMBL4586255 | — | Ki | = | 1178.0 | nM | 5.93 |
| CHEMBL4449637 | — | Ki | = | 1282.0 | nM | 5.89 |
| CHEMBL4531304 | — | Ki | = | 1364.0 | nM | 5.87 |
| CHEMBL4536306 | — | Ki | = | 1790.0 | nM | 5.75 |
| CHEMBL4435951 | — | Ki | = | 1899.0 | nM | 5.72 |
| CHEMBL4444406 | — | Ki | = | 2565.0 | nM | 5.59 |
| CHEMBL4440314 | — | Ki | = | 2796.0 | nM | 5.55 |
| CHEMBL4469385 | — | Ki | = | 3238.0 | nM | 5.49 |
| CHEMBL4474233 | — | Ki | = | 3949.0 | nM | 5.40 |
| CHEMBL4442867 | — | Ki | = | 4965.0 | nM | 5.30 |
| CHEMBL4521083 | — | Ki | = | 7507.0 | nM | 5.12 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 8550.0 | nM | 5.07 |