Assay Detail
Functional
CHEMBL4379933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A375 cells assessed as reduction in cell viability
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of MEK PROTACs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.72 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103875 | TRAMETINIB | 4.0 | 1 | 9.13 |
| CHEMBL2146883 | COBIMETINIB | 4.0 | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103875 | TRAMETINIB | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL2146883 | COBIMETINIB | IC50 | = | 5.0 | nM | 8.30 |