Assay Detail
Binding
CHEMBL4380089
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Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.99 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 8.94 |
| CHEMBL299031 | — | — | 1 | 5.03 |
| CHEMBL60533 | CORYNANRHEIDINE | — | 1 | - |
| CHEMBL25554 | — | — | 1 | - |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15245 | YOHIMBINE | Ki | = | 1.16 | nM | 8.94 |
| CHEMBL299031 | — | Ki | = | 9290.0 | nM | 5.03 |
| CHEMBL60533 | CORYNANRHEIDINE | Ki | - | — | - | |
| CHEMBL25554 | — | Ki | - | — | - | |
| CHEMBL2 | PRAZOSIN | Ki | - | — | - |