Assay Detail
Binding
CHEMBL4380412
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cathepsin G using Suc-AAPF-MCA as substrate at pH 7.2 and 298 K measured every 60 secs for 600 secs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Binding Loop Substitutions in the Cyclic Peptide SFTI-1 Generate Potent and Selective Chymase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.31 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592765 | — | — | 1 | 9.59 |
| CHEMBL4469390 | — | — | 1 | 8.13 |
| CHEMBL4586444 | — | — | 1 | 8.09 |
| CHEMBL4590739 | — | — | 1 | 7.85 |
| CHEMBL4457132 | — | — | 1 | 7.27 |
| CHEMBL4560112 | — | — | 1 | 6.82 |
| CHEMBL4465306 | — | — | 1 | 6.80 |
| CHEMBL4554739 | — | — | 1 | 5.92 |
| CHEMBL4556207 | — | — | 1 | 5.28 |
| CHEMBL4450993 | — | — | 1 | - |
| CHEMBL4472737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592765 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL4469390 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4586444 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4590739 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4457132 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL4560112 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4465306 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4554739 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL4556207 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL4450993 | — | Ki | < | 0.1 | nM | - |
| CHEMBL4472737 | — | Ki | - | — | - |