Assay Detail
Functional
CHEMBL4380649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Hopping of Natural Product Evodiamine: Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 5.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4537640 | — | — | 1 | 8.70 |
| CHEMBL4530236 | — | — | 1 | 8.00 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.70 |
| CHEMBL4467299 | — | — | 1 | 7.52 |
| CHEMBL4564211 | — | — | 1 | 7.22 |
| CHEMBL4459036 | — | — | 1 | 6.08 |
| CHEMBL4557430 | — | — | 1 | 5.82 |
| CHEMBL4448269 | — | — | 1 | 5.48 |
| CHEMBL4441228 | — | — | 1 | 5.36 |
| CHEMBL4439487 | — | — | 1 | 5.26 |
| CHEMBL4458074 | — | — | 1 | 5.25 |
| CHEMBL4471273 | — | — | 1 | 5.24 |
| CHEMBL4443790 | — | — | 1 | 5.21 |
| CHEMBL4538699 | — | — | 1 | 5.17 |
| CHEMBL4539993 | — | — | 1 | 5.14 |
| CHEMBL4474144 | — | — | 1 | 5.04 |
| CHEMBL4464937 | — | — | 1 | 5.03 |
| CHEMBL4474955 | — | — | 1 | 5.02 |
| CHEMBL4551086 | — | — | 1 | 4.92 |
| CHEMBL4557522 | — | — | 1 | 4.74 |
| CHEMBL4451137 | — | — | 1 | 4.71 |
| CHEMBL4444907 | — | — | 1 | 4.66 |
| CHEMBL4543417 | — | — | 1 | 4.54 |
| CHEMBL4468240 | — | — | 1 | 4.47 |
| CHEMBL4441086 | — | — | 1 | 4.35 |
| CHEMBL4472475 | — | — | 1 | 4.32 |
| CHEMBL4476274 | — | — | 1 | 4.31 |
| CHEMBL4461360 | — | — | 1 | 4.25 |
| CHEMBL4531426 | — | — | 1 | 4.24 |
| CHEMBL4441012 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4537640 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4530236 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4467299 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4564211 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4459036 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4557430 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4448269 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4441228 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4439487 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4458074 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4471273 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4443790 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4538699 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4539993 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4474144 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4464937 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4474955 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4551086 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4557522 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4451137 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4444907 | — | IC50 | = | 21930.0 | nM | 4.66 |
| CHEMBL4543417 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL4468240 | — | IC50 | = | 34150.0 | nM | 4.47 |
| CHEMBL4441086 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL4472475 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL4476274 | — | IC50 | = | 49200.0 | nM | 4.31 |
| CHEMBL4461360 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL4531426 | — | IC50 | = | 57850.0 | nM | 4.24 |
| CHEMBL4441012 | — | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL4445249 | — | IC50 | = | 66820.0 | nM | 4.17 |
| CHEMBL4475992 | — | IC50 | = | 87150.0 | nM | 4.06 |
| CHEMBL4549677 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4459414 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4454524 | — | IC50 | = | 180500.0 | nM | - |
| CHEMBL4436593 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4447339 | — | IC50 | = | 105900.0 | nM | - |
| CHEMBL4562784 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4453970 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4553396 | — | IC50 | = | 189700.0 | nM | - |
| CHEMBL4557193 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4469999 | — | IC50 | = | 124200.0 | nM | - |
| CHEMBL4468463 | — | IC50 | > | 120600.0 | nM | - |
| CHEMBL4452471 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4461061 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL463165 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4445785 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4586546 | — | IC50 | > | 200000.0 | nM | - |