Assay Detail
Binding
CHEMBL4380978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MNK1 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 1 (CHEMBL4718) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Stepwise Evolution of Fragment Hits against MAPK Interacting Kinases 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.32 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545307 | MERESTINIB | 2.0 | 1 | 6.89 |
| CHEMBL574738 | AST-487 | 1.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545307 | MERESTINIB | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL574738 | AST-487 | IC50 | = | 1760.0 | nM | 5.75 |