Assay Detail
Binding
CHEMBL4381524
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Inhibition of human Huh7 cell derived acid sphingomyelinase using NBD-sphingomyelin as substrate after 30 mins by fluorescence based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.29 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4551503 | — | — | 1 | 6.50 |
| CHEMBL4464117 | — | — | 1 | 6.47 |
| CHEMBL4464068 | — | — | 1 | 6.44 |
| CHEMBL4167681 | — | — | 1 | 6.32 |
| CHEMBL4471880 | — | — | 1 | 6.06 |
| CHEMBL4449978 | — | — | 1 | 5.76 |
| CHEMBL4588641 | — | — | 1 | 5.71 |
| CHEMBL4465034 | — | — | 1 | 5.68 |
| CHEMBL4446879 | — | — | 1 | 5.44 |
| CHEMBL4462822 | — | — | 1 | 5.30 |
| CHEMBL4464771 | — | — | 1 | 5.11 |
| CHEMBL4520414 | — | — | 1 | 5.08 |
| CHEMBL4517596 | — | — | 1 | 5.05 |
| CHEMBL4472122 | — | — | 1 | 5.04 |
| CHEMBL4527311 | — | — | 1 | 4.86 |
| CHEMBL323197 | MANGOSTIN | — | 1 | 4.85 |
| CHEMBL4441973 | — | — | 1 | 4.80 |
| CHEMBL4470582 | — | — | 1 | 4.71 |
| CHEMBL4580368 | — | — | 1 | 4.67 |
| CHEMBL4549543 | — | — | 1 | 4.67 |
| CHEMBL4464443 | — | — | 1 | 4.46 |
| CHEMBL4527059 | — | — | 1 | 4.44 |
| CHEMBL4541230 | — | — | 1 | 4.28 |
| CHEMBL4531162 | — | — | 1 | - |
| CHEMBL4454903 | — | — | 1 | - |
| CHEMBL4450237 | — | — | 1 | - |
| CHEMBL4539103 | — | — | 1 | - |
| CHEMBL4534608 | — | — | 1 | - |
| CHEMBL4450680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4551503 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4464117 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4464068 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4167681 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4471880 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4449978 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4588641 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4465034 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL4446879 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL4462822 | — | IC50 | = | 4970.0 | nM | 5.30 |
| CHEMBL4464771 | — | IC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL4520414 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL4517596 | — | IC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL4472122 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL4527311 | — | IC50 | = | 13780.0 | nM | 4.86 |
| CHEMBL323197 | MANGOSTIN | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4441973 | — | IC50 | = | 15910.0 | nM | 4.80 |
| CHEMBL4470582 | — | IC50 | = | 19610.0 | nM | 4.71 |
| CHEMBL4580368 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL4549543 | — | IC50 | = | 21610.0 | nM | 4.67 |
| CHEMBL4464443 | — | IC50 | = | 34720.0 | nM | 4.46 |
| CHEMBL4527059 | — | IC50 | = | 36450.0 | nM | 4.44 |
| CHEMBL4541230 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL4531162 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4454903 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4450237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4539103 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4534608 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4450680 | — | IC50 | > | 100000.0 | nM | - |