Assay Detail
Binding
CHEMBL4381549
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Inhibition of recombinant human acid sphingomyelinase (His62 to Pro628 residues) using NBD-sphingomyelin as substrate after 30 mins by fluorescence based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.57 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4517596 | — | — | 1 | 6.44 |
| CHEMBL4167681 | — | — | 1 | 6.05 |
| CHEMBL4464068 | — | — | 1 | 5.66 |
| CHEMBL4465034 | — | — | 1 | 5.47 |
| CHEMBL4551503 | — | — | 1 | 5.47 |
| CHEMBL4462822 | — | — | 1 | 5.42 |
| CHEMBL4471880 | — | — | 1 | 5.39 |
| CHEMBL4449978 | — | — | 1 | 5.37 |
| CHEMBL4464771 | — | — | 1 | 5.31 |
| CHEMBL4464117 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4517596 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4167681 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4464068 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4465034 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL4551503 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL4462822 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL4471880 | — | IC50 | = | 4090.0 | nM | 5.39 |
| CHEMBL4449978 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL4464771 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL4464117 | — | IC50 | = | 8070.0 | nM | 5.09 |