Assay Detail
Functional
CHEMBL4381714
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Antiproliferative activity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Parthenolide Dimers as Activators of Pyruvate Kinase M2 in Xenografts of Glioblastoma Multiforme in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.18 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.82 |
| CHEMBL4466655 | — | — | 1 | 5.52 |
| CHEMBL4591115 | — | — | 1 | 5.51 |
| CHEMBL4298697 | — | — | 1 | 5.36 |
| CHEMBL4450269 | — | — | 1 | 5.04 |
| CHEMBL4438521 | — | — | 1 | 4.97 |
| CHEMBL4543609 | — | — | 1 | 4.89 |
| CHEMBL4483778 | — | — | 1 | 4.82 |
| CHEMBL4577179 | — | — | 1 | 4.79 |
| CHEMBL1085588 | — | — | 1 | 4.06 |
| CHEMBL4459552 | — | — | 1 | - |
| CHEMBL4448585 | — | — | 1 | - |
| CHEMBL4454912 | — | — | 1 | - |
| CHEMBL4449654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4466655 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4591115 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL4298697 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL4450269 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL4438521 | — | IC50 | = | 10590.0 | nM | 4.97 |
| CHEMBL4543609 | — | IC50 | = | 12920.0 | nM | 4.89 |
| CHEMBL4483778 | — | IC50 | = | 15070.0 | nM | 4.82 |
| CHEMBL4577179 | — | IC50 | = | 16170.0 | nM | 4.79 |
| CHEMBL1085588 | — | IC50 | = | 86300.0 | nM | 4.06 |
| CHEMBL4459552 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4448585 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4454912 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4449654 | — | IC50 | > | 50000.0 | nM | - |