Assay Detail
Binding
CHEMBL4381861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat alpha2beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha2/beta2 (CHEMBL1907592) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.42 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4553407 | — | — | 1 | 6.36 |
| CHEMBL4460879 | — | — | 1 | 5.79 |
| CHEMBL4554920 | — | — | 1 | 5.67 |
| CHEMBL4455583 | — | — | 1 | 5.65 |
| CHEMBL4577696 | — | — | 1 | 5.52 |
| CHEMBL4522506 | — | — | 1 | 5.51 |
| CHEMBL4473421 | — | — | 1 | 5.40 |
| CHEMBL4460411 | — | — | 1 | 5.36 |
| CHEMBL4540592 | — | — | 1 | 5.31 |
| CHEMBL4463717 | — | — | 1 | 5.12 |
| CHEMBL4448288 | — | — | 1 | 5.12 |
| CHEMBL4525995 | — | — | 1 | 5.04 |
| CHEMBL4450578 | — | — | 1 | 5.04 |
| CHEMBL4446775 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4553407 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4460879 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4554920 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4455583 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4577696 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL4522506 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL4473421 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL4460411 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL4540592 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4463717 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL4448288 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL4525995 | — | IC50 | = | 9060.0 | nM | 5.04 |
| CHEMBL4450578 | — | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL4446775 | — | IC50 | = | 9450.0 | nM | 5.03 |