Assay Detail
Functional
CHEMBL4381889
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Growth inhibition of human 1321N1 cells incubated for 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.30 | 9.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411767 | ARCHAZOLID B | — | 1 | 9.84 |
| CHEMBL241106 | ARCHAZOLID A | — | 1 | 9.60 |
| CHEMBL4471610 | — | — | 1 | 9.12 |
| CHEMBL4593430 | — | — | 1 | 8.67 |
| CHEMBL4460252 | — | — | 1 | 8.59 |
| CHEMBL290814 | BAFILOMYCIN A1 | — | 1 | 8.51 |
| CHEMBL1784269 | ARCHAZOLID F | — | 1 | 8.35 |
| CHEMBL4549217 | — | — | 1 | 6.53 |
| CHEMBL4447903 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411767 | ARCHAZOLID B | IC50 | = | 0.145 | nM | 9.84 |
| CHEMBL241106 | ARCHAZOLID A | IC50 | = | 0.253 | nM | 9.60 |
| CHEMBL4471610 | — | IC50 | = | 0.757 | nM | 9.12 |
| CHEMBL4593430 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL4460252 | — | IC50 | = | 2.58 | nM | 8.59 |
| CHEMBL290814 | BAFILOMYCIN A1 | IC50 | = | 3.06 | nM | 8.51 |
| CHEMBL1784269 | ARCHAZOLID F | IC50 | = | 4.51 | nM | 8.35 |
| CHEMBL4549217 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL4447903 | — | IC50 | = | 3050.0 | nM | 5.52 |