Assay Detail
Binding
CHEMBL4381892
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Displacement of [3H]PSB-11 from human A3 adenosine receptor expressed in CHO cell membranes incubated for 60 mins by liquid scintillation counting method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of Novel Potent Archazolids: Pharmacology of an Emerging Class of Anticancer Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.97 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4471610 | — | — | 1 | 6.21 |
| CHEMBL1784269 | ARCHAZOLID F | — | 1 | 6.07 |
| CHEMBL241106 | ARCHAZOLID A | — | 1 | 6.01 |
| CHEMBL290814 | BAFILOMYCIN A1 | — | 1 | 5.97 |
| CHEMBL4593430 | — | — | 1 | 5.94 |
| CHEMBL411767 | ARCHAZOLID B | — | 1 | 5.93 |
| CHEMBL4447903 | — | — | 1 | 5.86 |
| CHEMBL4549217 | — | — | 1 | 5.79 |
| CHEMBL4460252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4471610 | — | Ki | = | 609.0 | nM | 6.21 |
| CHEMBL1784269 | ARCHAZOLID F | Ki | = | 859.0 | nM | 6.07 |
| CHEMBL241106 | ARCHAZOLID A | Ki | = | 967.0 | nM | 6.01 |
| CHEMBL290814 | BAFILOMYCIN A1 | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL4593430 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL411767 | ARCHAZOLID B | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL4447903 | — | Ki | = | 1376.0 | nM | 5.86 |
| CHEMBL4549217 | — | Ki | = | 1611.0 | nM | 5.79 |
| CHEMBL4460252 | — | Ki | >= | 10000.0 | nM | - |