Assay Detail
Functional
CHEMBL4381955
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Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by MTT assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 6.03 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568628 | — | — | 1 | 7.43 |
| CHEMBL4441847 | — | — | 1 | 7.15 |
| CHEMBL4445234 | — | — | 1 | 7.08 |
| CHEMBL4582983 | — | — | 1 | 7.01 |
| CHEMBL4580982 | — | — | 1 | 6.96 |
| CHEMBL4462450 | — | — | 1 | 6.89 |
| CHEMBL4581625 | — | — | 1 | 6.80 |
| CHEMBL4457918 | — | — | 1 | 6.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.57 |
| CHEMBL4458966 | — | — | 1 | 6.51 |
| CHEMBL4458487 | — | — | 1 | 6.25 |
| CHEMBL4571947 | — | — | 1 | 6.24 |
| CHEMBL4435244 | — | — | 1 | 6.18 |
| CHEMBL4590197 | — | — | 1 | 6.11 |
| CHEMBL4462121 | — | — | 1 | 6.05 |
| CHEMBL4459816 | — | — | 1 | 5.96 |
| CHEMBL4581891 | — | — | 1 | 5.91 |
| CHEMBL4543491 | — | — | 1 | 5.85 |
| CHEMBL4522620 | — | — | 1 | 5.81 |
| CHEMBL4459293 | — | — | 1 | 5.79 |
| CHEMBL4444571 | — | — | 1 | 5.59 |
| CHEMBL4513280 | — | — | 1 | 5.50 |
| CHEMBL4443166 | — | — | 1 | 5.47 |
| CHEMBL4580757 | — | — | 1 | 5.41 |
| CHEMBL4469299 | — | — | 1 | 5.18 |
| CHEMBL4437875 | — | — | 1 | 5.01 |
| CHEMBL4465967 | — | — | 1 | 5.00 |
| CHEMBL4553228 | — | — | 1 | 4.81 |
| CHEMBL55934 | NAPHTHOQUINONE | — | 1 | 4.77 |
| CHEMBL4546473 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568628 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4441847 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4445234 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4582983 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4580982 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4462450 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4581625 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4457918 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4458966 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4458487 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4571947 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4435244 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4590197 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4462121 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4459816 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL4581891 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4543491 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4522620 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4459293 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4444571 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL4513280 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4443166 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4580757 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4469299 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL4437875 | — | IC50 | = | 9720.0 | nM | 5.01 |
| CHEMBL4465967 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL4553228 | — | IC50 | = | 15380.0 | nM | 4.81 |
| CHEMBL55934 | NAPHTHOQUINONE | IC50 | = | 17080.0 | nM | 4.77 |
| CHEMBL4546473 | — | IC50 | = | 17230.0 | nM | 4.76 |
| CHEMBL4434768 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4535878 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4544661 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4536106 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4467021 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4525225 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4540285 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4515286 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4534666 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4567684 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4469127 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4451709 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4568944 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4564513 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4463478 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4460536 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4444526 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4453836 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4519463 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4529614 | — | IC50 | > | 10000.0 | nM | - |