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Assay Detail

CHEMBL4381980

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TDO (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tryptophan 2,3-dioxygenase (CHEMBL2140)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Bifunctional Naphthoquinone Aromatic Amide-Oxime Derivatives Exert Combined Immunotherapeutic and Antitumor Effects through Simultaneous Targeting of Indoleamine-2,3-dioxygenase and Signal Transducer and Activator of Transcription 3.
Huang R, Jing X, Huang X, Pan Y, Fang Y, Liang G, Liao Z, Wang H, Chen Z, Zhang Y.
J Med Chem (2020) 63 : 1544 -1563
PubMed 31999451 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.52 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3628599 1 7.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3628599 IC50 = 30.0 nM 7.52