Assay Detail
Binding
CHEMBL4382900
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Poison activity at recombinant human topoisomerase 2beta using pBR322 plasmid as substrate after 30 mins by ethidium bromide staining based agarose gel electrophoresis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.01 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 7.52 |
| CHEMBL4553471 | — | — | 1 | 5.97 |
| CHEMBL4575796 | — | — | 1 | 5.94 |
| CHEMBL4448353 | — | — | 1 | 5.36 |
| CHEMBL4467805 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49442 | AMETANTRONE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4553471 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4575796 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4448353 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL4467805 | — | IC50 | = | 5250.0 | nM | 5.28 |