Assay Detail
Functional
CHEMBL4382968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MOLM13 cells after 96 hrs by CCK8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.50 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572428 | — | — | 1 | 10.21 |
| CHEMBL4558092 | — | — | 1 | 9.74 |
| CHEMBL4550750 | — | — | 1 | 9.72 |
| CHEMBL4546160 | — | — | 1 | 9.72 |
| CHEMBL4519362 | — | — | 1 | 9.29 |
| CHEMBL4449128 | — | — | 1 | 9.28 |
| CHEMBL4573649 | — | — | 1 | 9.25 |
| CHEMBL4520683 | — | — | 1 | 8.80 |
| CHEMBL4472522 | — | — | 1 | 8.66 |
| CHEMBL4565270 | — | — | 1 | 8.65 |
| CHEMBL4215078 | — | — | 1 | 8.13 |
| CHEMBL4226052 | — | — | 1 | 7.74 |
| CHEMBL4094346 | — | — | 1 | 6.85 |
| CHEMBL4436396 | — | — | 1 | 6.74 |
| CHEMBL4555209 | — | — | 1 | 6.68 |
| CHEMBL4469991 | — | — | 1 | 6.51 |
| CHEMBL4529557 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572428 | — | IC50 | = | 0.062 | nM | 10.21 |
| CHEMBL4558092 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL4550750 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4546160 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4519362 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4449128 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4573649 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL4520683 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4472522 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4565270 | — | IC50 | = | 2.23 | nM | 8.65 |
| CHEMBL4215078 | — | IC50 | = | 7.45 | nM | 8.13 |
| CHEMBL4226052 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL4094346 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4436396 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4555209 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL4469991 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL4529557 | — | IC50 | > | 1000.0 | nM | - |