Assay Detail
Binding
CHEMBL4383378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from Lymnaea stagnalis acetylcholine-binding protein incubated for 60 mins followed by 3 hrs incubation in dark condition by microbeta counting analysis
30
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lymnaea stagnalis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.01 | 9.07 |
| IC50 | 1 | 6.98 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554047 | — | — | 1 | 9.07 |
| CHEMBL4440256 | — | — | 1 | 8.64 |
| CHEMBL4437999 | — | — | 1 | 8.47 |
| CHEMBL4458658 | — | — | 1 | 8.46 |
| CHEMBL4557873 | — | — | 1 | 8.28 |
| CHEMBL4551353 | — | — | 1 | 8.28 |
| CHEMBL4541936 | — | — | 1 | 8.25 |
| CHEMBL4444365 | — | — | 1 | 8.23 |
| CHEMBL4467323 | — | — | 1 | 8.22 |
| CHEMBL4447538 | — | — | 1 | 8.01 |
| CHEMBL4537917 | — | — | 1 | 7.94 |
| CHEMBL4437423 | — | — | 1 | 7.93 |
| CHEMBL4558905 | — | — | 1 | 7.92 |
| CHEMBL4452235 | — | — | 1 | 7.91 |
| CHEMBL4556242 | — | — | 1 | 7.90 |
| CHEMBL4447431 | — | — | 1 | 7.89 |
| CHEMBL4444981 | — | — | 1 | 7.80 |
| CHEMBL4540765 | — | — | 1 | 7.78 |
| CHEMBL4579917 | — | — | 1 | 7.78 |
| CHEMBL4451952 | — | — | 1 | 7.76 |
| CHEMBL4448437 | — | — | 1 | 7.72 |
| CHEMBL4537587 | — | — | 1 | 7.65 |
| CHEMBL4449862 | — | — | 1 | 7.58 |
| CHEMBL4533711 | — | — | 1 | 7.54 |
| CHEMBL4559828 | — | — | 2 | 7.15 |
| CHEMBL4559380 | — | — | 1 | - |
| CHEMBL4436100 | — | — | 1 | - |
| CHEMBL4520291 | — | — | 1 | - |
| CHEMBL4450187 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554047 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL4440256 | — | Ki | = | 2.27 | nM | 8.64 |
| CHEMBL4437999 | — | Ki | = | 3.39 | nM | 8.47 |
| CHEMBL4458658 | — | Ki | = | 3.47 | nM | 8.46 |
| CHEMBL4551353 | — | Ki | = | 5.22 | nM | 8.28 |
| CHEMBL4557873 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL4541936 | — | Ki | = | 5.57 | nM | 8.25 |
| CHEMBL4444365 | — | Ki | = | 5.93 | nM | 8.23 |
| CHEMBL4467323 | — | Ki | = | 6.02 | nM | 8.22 |
| CHEMBL4447538 | — | Ki | = | 9.77 | nM | 8.01 |
| CHEMBL4537917 | — | Ki | = | 11.41 | nM | 7.94 |
| CHEMBL4437423 | — | Ki | = | 11.72 | nM | 7.93 |
| CHEMBL4558905 | — | Ki | = | 11.92 | nM | 7.92 |
| CHEMBL4452235 | — | Ki | = | 12.42 | nM | 7.91 |
| CHEMBL4556242 | — | Ki | = | 12.48 | nM | 7.90 |
| CHEMBL4447431 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4444981 | — | Ki | = | 15.96 | nM | 7.80 |
| CHEMBL4540765 | — | Ki | = | 16.47 | nM | 7.78 |
| CHEMBL4579917 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL4451952 | — | Ki | = | 17.22 | nM | 7.76 |
| CHEMBL4448437 | — | Ki | = | 18.84 | nM | 7.72 |
| CHEMBL4537587 | — | Ki | = | 22.23 | nM | 7.65 |
| CHEMBL4449862 | — | Ki | = | 26.19 | nM | 7.58 |
| CHEMBL4533711 | — | Ki | = | 29.02 | nM | 7.54 |
| CHEMBL4559828 | — | Ki | = | 71.5 | nM | 7.15 |
| CHEMBL4559828 | — | IC50 | = | 105.6 | nM | 6.98 |
| CHEMBL4559380 | — | Ki | > | 67.7 | nM | - |
| CHEMBL4436100 | — | Ki | > | 67.7 | nM | - |
| CHEMBL4520291 | — | Ki | > | 67.7 | nM | - |
| CHEMBL4450187 | — | Ki | > | 67.7 | nM | - |