Assay Detail
Binding
CHEMBL4383515
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Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.41 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432537 | — | — | 1 | 7.00 |
| CHEMBL1098875 | — | — | 1 | 6.03 |
| CHEMBL72165 | — | — | 1 | 6.03 |
| CHEMBL3087009 | — | — | 1 | 5.83 |
| CHEMBL312537 | — | — | 1 | 5.49 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 5.41 |
| CHEMBL3086870 | — | — | 1 | 5.01 |
| CHEMBL1812545 | — | — | 1 | 4.73 |
| CHEMBL3087010 | — | — | 1 | 4.35 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 4.19 |
| CHEMBL1276265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432537 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL1098875 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL72165 | — | IC50 | = | 937.0 | nM | 6.03 |
| CHEMBL3087009 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL312537 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 3940.0 | nM | 5.41 |
| CHEMBL3086870 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL1812545 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL3087010 | — | IC50 | = | 44800.0 | nM | 4.35 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 64500.0 | nM | 4.19 |
| CHEMBL1276265 | — | IC50 | = | 224200.0 | nM | - |